Germany GSK developed the first European personal use bird flu vaccine-GSK, bird flu vaccine for human use - pharmaceutical industries
Announced, Germany GlaxoSmithKline (GlaxoSmithKline) has developed a new type of people on its use Avian flu vaccine Application to the Board for approval, is expected by the end of March 2006 to conduct clinical research.
The vaccine research and development to follow a new way. The United States has developed a targeted H5N1 Virus vaccine, but production of this vaccine are cumbersome and expensive, so in case of emergency can only be provided to the minority. And can only really be related with the H5N1 virus effectively, but effects are limited. As can be generated by the H5N1 transmission between the virus has mutated, take on the unknown virus vaccine prepared in advance, but in principle it is very difficult. Thus, the German Bureau of serum and vaccine experts has proposed a new way: with Pharmacy Companies to obtain a kind of prototype virus (Virus-Prototyp), the prototype of this virus as a vaccine for use after the basic framework. The event of a pandemic of avian influenza virus, the researchers do not have to start from scratch to develop new vaccines, but the prototype virus and pathogens match the exact characteristics, thus won the development of efficient vaccines against new viruses valuable time. Ms. Susanne Stochcker PEI spokesman said, "No matter what the virus causing bird flu pandemic, using our prototype virus can quickly respond."
Fact, this is a new vaccine can be quickly put into production of "carrier (Vehikel)". In urgent cases, a super-inactivated virus (Supervirus) can be implanted into the overall carrier. To speed up vaccine production rate, we must dilute the vaccine antigen dose, the overall reduction units Vaccination Dose required to inactivate the virus. In order to ensure full and effective, we must add the appropriate adjuvant (Adjuvantien), which increase Immunity Of material. So far, most of the influenza virus vaccine without adjuvant. The use of the full production of the vaccine virus, rather than the virus currently only use this piece, you can make vaccine production more efficient. According to this idea is possible in the shortest possible time, millions of people Organization Medium was a vaccine. Therefore, the company decided to develop the country Glaxo Shike De adjuvant that contains a complete virus vaccine prototype, so the antigen dose required for only one-third of the existing methods. Glaxo Shike De countries, the company said the vaccine prototype, once successful, not only can produce enough vaccine to prevent H5N1 virus is also able to produce enough to prevent any kind of influenza virus vaccines. PEI spokesman said that once the prototype of this vaccine is approved, even if the bird flu pandemic, the vaccine can be used to produce a prototype in 16 weeks, 80 million were vaccinated, and after six weeks in the reproduction of the same more use of vaccines for revaccination.
This new vaccine research and development funding by the German federal government. In early 2005, the German federal government decided to allocate 20 million euros funding for human use bird flu vaccine research and development. By inviting tenders (Auswahlgesprochch), the German government to open selected GlaxoSmithKline and Swiss companies
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